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| Specification: | 80,98% | Active Ingredients: | 7-ethyl-10-hydroxycamptothecin |
|---|---|---|---|
| Part: | Tree Bark And Fruit | Extraction Type: | Solvent Extraction |
| Application: | Medicals | Form: | Powder |
| Cas: | 86639-52-3 | Appearance: | Light Yellow |
| Test Method: | HPLC | ||
| High Light: | organic plant extracts,herbal plant extract |
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Herbal Extract Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Herbal Extract Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
It is widely believed that Herbal Extract Camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, Herbal Extract Camptothecin is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, Herbal Extract Camptothecin ultimately causes cell death.
At present, some Camptothecin analogs, either semi-synthetic or synthetic drug based on Camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
| Product Name | 7-ethyl-10-hydroxycamptothecin |
| Other name | 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Used Part | Leaf |
| Active Ingredient | 7-ethyl-10-hydroxycamptothecin |
| Specs | 98% by HPLC |
| Particle Size | 100% pass through 80 mesh sieve |
| Heavy metals(as Pb) | <10ppm |
| Arsenic(as AS2O3) | <2ppm |
| Total bacterial count | Max.1000cfu/g |
| Yeast & Mould | Max.100cfu /g |
| Escherichia coli presence | Negative |
| Salmonella | Negative |
| Molecular Formula | C22H20N205 |
| Molecular Weight | 392.40 |
Certificate of Analysis
| Analysis | Specification | Results |
| Assay(By HPLC) | 7-Ethyl-10-hydroxycamptothecin>98% | 98.56% |
| Chemical Control | ||
| Identification | Verfied | |
| Heavy metals | <10ppm | Complies |
| Pesticides | Negative | Negative |
| Physical Control | ||
| Appearance | Light yellow crystalline powder | Complies |
| Color | Light yellow | Complies |
| Odor | Characteristic | Complies |
| Taste | Characteristic | Complies |
| Mesh Size | 100% through 80 mesh | Complies |
| Loss On Drying | <5% | 2.50% |
| Microbiological | ||
| Total Plate Count | <1000CFU/gm | Complies |
| Yeast & Mold | <100CFU/gm | Complies |
| Salmonella | Negative | Negative |
| E.Coli | Negative | Negative |
| Storage | Cool and Dry | |
| Shelf life | 2 years |
Function of 7-ethyl-10-Hydroxycamptothecin
1. 7-ethyl-10-Hydroxycamptothecin can make changes in skin epidermal keratinization process.
2. 7-ethyl-10-Hydroxycamptothecin can anti-cancer, anti-virus, anti early pregnancy.
3. 7-ethyl-10-Hydroxycamptothecin has the function of treatment of gastric cancer, liver cancer, head and neck cancer and leukemia.
Application of 7-ethyl-10-Hydroxycamptothecin:
1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.
4. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
Packing:1kg/bag,25kg/drum
Lead time:5-8 workding days
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