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Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder

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Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder

China Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier
Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier Cas No 86639-52-3 Pure Natural Plant Extracts 7- Ethyl - 10- Hydroxycamptothecin Powder supplier

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Product Details:

Place of Origin: China
Brand Name: STAHERB
Certification: ISO,KOSHER
Model Number: STA-83

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Price: negotiation
Packaging Details: 1kg/bag,25kg/drum
Delivery Time: 5-8 working days
Payment Terms: L/C, T/T, Western Union
Supply Ability: 100000kgs
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Detailed Product Description
Specification: 80,98% Active Ingredients: 7-ethyl-10-hydroxycamptothecin
Part: Tree Bark And Fruit Extraction Type: Solvent Extraction
Application: Medicals Form: Powder
Cas: 86639-52-3 Appearance: Light Yellow
Test Method: HPLC

What is 7-Ethyl-10-hydroxycamptothecin?

Herbal Extract Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. Herbal Extract Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.

It is widely believed that Herbal Extract Camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, Herbal Extract Camptothecin is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, Herbal Extract Camptothecin ultimately causes cell death.
At present, some Camptothecin analogs, either semi-synthetic or synthetic drug based on Camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

 

 

Product Name 7-ethyl-10-hydroxycamptothecin
Other name 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Used Part Leaf
Active Ingredient 7-ethyl-10-hydroxycamptothecin
Specs 98% by HPLC
Particle Size 100% pass through 80 mesh sieve
Heavy metals(as Pb) <10ppm
Arsenic(as AS2O3) <2ppm
Total bacterial count Max.1000cfu/g
Yeast & Mould Max.100cfu /g
Escherichia coli presence Negative
Salmonella Negative
Molecular Formula C22H20N205
Molecular Weight 392.40

 

 

Certificate of Analysis

 

 
Analysis Specification Results
Assay(By HPLC) 7-Ethyl-10-hydroxycamptothecin>98% 98.56%
Chemical Control    
Identification   Verfied
Heavy metals <10ppm Complies
Pesticides Negative Negative
Physical Control    
Appearance Light yellow crystalline powder Complies
Color Light yellow Complies
Odor Characteristic Complies
Taste Characteristic Complies
Mesh Size 100% through 80 mesh Complies
Loss On Drying <5% 2.50%
Microbiological    
Total Plate Count <1000CFU/gm Complies
Yeast & Mold <100CFU/gm Complies
Salmonella Negative Negative
E.Coli Negative Negative
Storage Cool and Dry  
Shelf life 2 years  

 

Function of 7-ethyl-10-Hydroxycamptothecin

 

1. 7-ethyl-10-Hydroxycamptothecin can make changes in skin epidermal keratinization process.


2. 7-ethyl-10-Hydroxycamptothecin can anti-cancer, anti-virus, anti early pregnancy.


3. 7-ethyl-10-Hydroxycamptothecin has the function of treatment of gastric cancer, liver cancer, head and neck cancer and leukemia.


 

Application of 7-ethyl-10-Hydroxycamptothecin:

 

1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.


2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.


3. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.


4. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

 

 

Packing:1kg/bag,25kg/drum
Lead time:5-8 workding days

 

 

Contact Details
Changsha Staherb Natural Ingredients Co., Ltd

Contact Person: Emily

Tel: +8613507420713

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